研究業績

2023年

原著論文

• "Total biosynthesis of melleolides from Basidiomycota fungi: Mechanistic analysis of the multi-functional GMC oxidase Mld7"
  Fukaya, M.#; Nagamine, S.#; Ozeki, M.; Matsuyama, T.; Sato, M.; Miyamoto, K.; Kawagishi H.; Watanabe, K.; Ozaki, T.; Uchiyama, M.; Oikawa, H.*; Minami, A.*
  Angew. Chem. Int. Ed. 62, e202308881 (2023).

  • DOI: 10.1002/anie.202308881

  異分野融合：河岸先生（静岡大学）、内山先生（東京大学）
• "A fungal sesquiterpene biosynthesis gene cluster critical for mutualist-pathogen transition in Colletotrichum tofieldiae"
  Hiruma, K.*; Aoki, S.; Takino, J.; Higa, T.; Utami, Y. D.; Shiina, A.; Okamoto, M.; Nakamura, M.; Kawamura, N.; Ohmori, Y.; Sugita, R.; Tanoi, K.; Sato, T.; Oikawa, H.; Minami, A.; Iwasaki, W.; Saijo, Y.
  Nat. Commun. 14, 5228 (2023).

  • DOI: 10.1038/s41467-023-40867-w

  異分野融合：晝間先生（東京大学）
• "Oxidative bicyclic ring system formation involving indole diterpene biosynthesis: Remarkable substrate tolerance of a prenyltransferase and flavoprotein oxidase"
  Liu, Y.; Ozaki, T.; Minami, A.*; Oikawa, H.*
  Tetrahedron Lett. 117, 154374 (2023).

  • DOI: 10.1016/j.tetlet.2023.154374
• "Structural Basis of Amide-Forming Adenylation Enzyme VinM in Vicenistatin Biosynthesis"
  *Miyanaga, A; Nagata, K; Nakajima, J; Chisuga, T; Kudo, F; *Eguchi, T
  ACS Chem. Biol. 18, 11, 2343-2348 (2023).

  • DOI: 10.1021/acschembio.3c00517
• "Structure-Based Analysis of Transient Interactions between Ketosynthase-like Decarboxylase and Acyl Carrier Protein in a Loading Module of Modular Polyketide Synthase"
  Chisuga, T; Murakami, S; *Miyanaga, A; Kudo, F; *Eguchi, T
  ACS Chem. Biol. 18, 6, 1398-1404 (2023).

  • DOI: 10.1021/acschembio.3c00151
• "Unique Initiation and Termination Mechanisms Involved in the Biosynthesis of a Hybrid Polyketide-Nonribosomal Peptide Lyngbyapeptin B Produced by the Marine Cyanobacterium Moorena bouillonii"
  *Kudo, F; Chikuma, T; Nambu, M; Chisuga, T; Sumimoto, S; Iwasaki, A; Suenaga, K; Miyanaga, A; *Eguchi, T
  ACS Chem. Biol. 18, 4, 875-883 (2023).

  • DOI: 10.1021/acschembio.3c00011
• "Acyltransferase Domain Exchange between Two Independent Type I Polyketide Synthases in the Same Producer Strain of Macrolide Antibiotics"
  *Kudo, F; Kishikawa, K; Tsuboi, K; Kido, T; Usui, T; Hashimoto, J; Shin-ya, K; Miyanaga, A; *Eguchi, T
  ChemBioChem 24, e202200670 (2023).

  • DOI: 10.1002/cbic.202200670
• "Structural Basis of Transient Interactions of Acyltransferase VinK with the Loading Acyl Carrier Protein of the Vicenistatin Modular Polyketide Synthase"
  *Miyanaga, A; Kawada, K; Chisuga, T; Kudo, F; *Eguchi, T
  Biochemistry 62, 1, 17-21 (2023).

  • DOI: 10.1021/acs.biochem.2c00645

総説

• "Recent advances in the biosynthesis of ribosomally synthesized and posttranslationally modified peptides of fungal origin"
  Ozaki, T.; Minami, A.; Oikawa, H.*
  J. Antibiot. 76, 3-13 (2023).

  • DOI: 10.1038/s41429-022-00576-w
• "Biosynthesis of indole diterpenes: Reconstitution approach in heterologous host"
  Ozaki, T.; Minami, A.*; Oikawa, H.*
  Nat. Prod. Rep. 40, 202-213 (2023).

  • DOI: 10.1039/D2NP00031H
• "Controlled chemical construction in nature: Unified biogenesis accounting for synthesis of fungal dimeric anhydrides"
  Minami, A.*
  Bull. Chem. Soc. Jpn. 96, 1216-1223 (2023).

  • DOI: 10.1246/bcsj.20230187
• "Cross-Linking of the Nonribosomal Peptide Synthetase Adenylation Domain with a Carrier Protein Using a Pantetheine-Type Probe"
  Miyanaga, A; Kudo, F; Eguchi, T
  Non-Ribosomal Peptide Biosynthesis and Engineering: Methods and Protocols, 207-217 (2023).

  • DOI: 10.1007/978-1-0716-3214-7_10

著書・解説

• "A new trend in biosynthetic studies of natural products: The bridge between the amino acid sequence data and the chemical structure"
  Minami, A.
  New Tide of Natural Product Chemistry (2023).