研究業績

研究業績
Genome-based discovery of enantiomeric pentacyclic sesterterpenes catalyzed by the fungal bifunctional terpene synthase

Org. Lett 23, 4645-4650 (2021)

Genome-based discovery of enantiomeric pentacyclic sesterterpenes catalyzed by the fungal bifunctional terpene synthase

著者

Jiang, L.; Zhang, X.; Sato, Y.; Zhu, G.; Minami, A.; Zhang, W.; Ozaki, T.; Zhu, B.; Wang, Z.; Wang, X.; Lv, K.; Zhang, J.; Wang, Y. -H.; Gao, S. -S.; Liu, C.; Hsiang, T.; Zhang, L.; Oikawa, H.*; Liu, X.*

カテゴリ

原著論文

DOI: 10.1021/acs.orglett.1c01361

Genome-based discovery of two previously unreported fungal bifunctional terpene synthases (BFTSs) from phytopathogenic fungi are reported: FoFS catalyzing the formation of fusoxypenes A–C (1–3) and (−)-astellatene (4) and AtAS capable of synthesizing preaspterpenacid I (6). Interestingly, FoFS and AtAS catalyzed the formation of enantiomeric sesterterpenes with a 5–6–7–3–5 ring system. C22-oxidative modification of preaspterpenacid I by AtP450 was characterized as well. Plausible cyclization pathways of the fusoxypenes were illustrated by DFT calculations.